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	Provedor de dados BJMBR (2) Autor Ariga,S. (1) Barbeiro,H.V. (1) Curi,R. (1) Deng,T. (1) Goloubkova,T. (1) Melo,E.S. (1) Shang,Z. (1) Soriano,F.G. (1) Vasconcelos,D. (1) Velasco,I.T. (1) Wang,D. (1) Xiao,Y. (1) Mais... Palavra-chave T helper cells (2) Adiponectin (1) CD40 (1) CD80 (1) Cytokines (1) HLA-DR (1) Immune tolerance (1) Lipopolysaccharide (1) Murine sepsis model (1) Sepsis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Adiponectin inhibits oxidization-induced differentiation of T helper cells through inhibiting costimulatory CD40 and CD80 BJMBR Xiao,Y.; Deng,T.; Shang,Z.; Wang,D.. Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, in this study, we aimed to observe the differentiation of T helper (Th) cells and expression of costimulatory signaling molecules affected by adiponectin. The mRNA and protein expression levels of adiponectin and its receptors in oxidized low density lipoprotein cholesterol-treated endothelial cells were assayed by real time PCR and immunofluorescence. The endothelial cells were then treated with adiponectin with or without adipoR1 or adipoR2 siRNA and co-cultured with T lymphocytes. The distribution of Th1, Th2 and Th17 subsets were assayed by flow cytometry. The effects of adiponectin on... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adiponectin; T helper cells; HLA-DR; CD80; CD40. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600606 Immune cells and oxidative stress in the endotoxin tolerance mouse model BJMBR Melo,E.S.; Barbeiro,H.V.; Ariga,S.; Goloubkova,T.; Curi,R.; Velasco,I.T.; Vasconcelos,D.; Soriano,F.G.. Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses during a septic event. We describe a lipopolysaccharide tolerance mouse model to characterize the cellular and molecular alterations of immune cells during sepsis. The model presents a typical lipopolysaccharide tolerance pattern in which tolerance is related to decreased production and secretion of cytokines after a subsequent exposure to a lethal dose of lipopolysaccharide. The initial lipopolysaccharide exposure also altered the expression patterns of cytokines and was followed by an 8- and a 1.5-fold increase in the T helper 1 and 2... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sepsis; Cytokines; Immune tolerance; Lipopolysaccharide; Murine sepsis model; T helper cells. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100009 Registros recuperados: 2 Primeira ... 1 ... Última

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